What is in a name? Integrating homeostasis, allostasis and stress

The Reactive Scope Model - a new model integrating homeostasis, allostasis, and stress.

Allostasis, the concept of maintaining stability through change, has been proposed as a term and a model to replace the ambiguous term of stress, the concept of adequately or inadequately coping with threatening or unpredictable environmental stimuli. However, both the term allostasis and its underlying model have generated criticism. Here we propose the Reactive Scope Model, an alternate graph...

What is in a Name?

Podocyturia: What is in a name?

The podocyte is a highly differentiated cell located in the outer space of the glomerular basement membrane that deals with many different functions. This phylogenetically preserved cell that is responsible for the virtually absence of proteins in the urine lacks of the capacity to divide under normal conditions. When podocytes receive molecular insults, which normally occur during stress condi...

Physiological genomics--what is in a name?

PHYSIOLOGY, THE SCIENTIFIC discipline of enquiry into how molecules, cells, and organs interact to function as a whole being, has been in existence since the times of the ancient Greeks. However, it was in the 18th and 19th centuries that physiology collided with advances in chemistry, physics, and biology to pave the way for new disciplines to emerge, such as biochemistry, biophysics, and more...

P-value: What is and what is not

The misinterpretation and misuse of p-value have been increasing for decades. In March 2016, the American Statistical Association released a statement to warn about the use and interpretation of p-value. In this study, we provided a definition and discussion of p-value and emphasized the importance of its accurate interpretation.